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Peyronie’s disease is where plaques (segments of flat scar tissue) form under the skin of the penis and cause curvature and pain.

These plaques can cause the penis to bend or become indented during erections. The plaques can often be felt through the skin and can be painful.

How does the penis normally work?

The main roles of the penis are to carry urine and sperm out of the body. There are 3 tubes inside the penis. One is called the urethra. It is hollow and carries urine from the bladder through the penis to the outside. The other 2 tubes are called the corpora cavernosa.

These are soft, spongy tubes that fill with blood to make the penis stiff during an erection. The 3 tubes are wrapped together by a very tough fibrous sheath called the tunica albuginea. During sex, the stiffness of the penis makes it hard enough to push into a woman’s vagina. Then the urethra acts as a channel to carry semen into the vagina.

Symptoms

Peyronie’s disease plaques mostly (70% of the time) form on the top (or dorsal side) of the penis. The plaques make the tunica albuginea less flexible and may cause the penis to bend upwards when it stiffens. When plaques form on the bottom or side of the penis, the bend will be downward or sideways. Some men have more than one plaque, which may cause complex curves.

Sometimes plaques form that go all the way around the penis. These plaques most often do not cause curving but may cause the shaft of the penis to narrow like the neck of a bottle.

This is sometimes called “bottle-necking” or “waisting”. In bad cases, the plaque may collect calcium and become very hard, almost like a bone. Men may also notice their penis has shrunk or gotten shorter.

Other signs that you may have Peyronie’s disease are:

  • bent/curved penis;
  • lumps in the penis;
  • painful erections;
  • soft erections;
  • having trouble with sex because of a bent/curved penis.

Peyronie’s disease can make your quality of life worse. Over 75 out of 100 men with Peyronie’s disease are stressed and depressed because of it. Unfortunately, many men with Peyronie’s disease are embarrassed and choose to suffer in silence rather than get help.

How common is Peyronie’s disease?

Peyronie’s disease is thought to happen in about 4 out of 100 men between the ages of 40 and 70. It is rare in young men but has been seen in men in their 30s. The number of cases may be higher than the estimates because many men may be embarrassed and choose not to see their health care provider.

Interestingly, more Peyronie’s disease cases have been noted in recent years. This may be because new drugs for erectile dysfunction (ED) have come to market and health care providers may notice Peyronie’s disease in men seeking help for ED. For this reason, the number of Peyronie’s disease cases reported may keep growing.

Causes

Peyronie’s disease is likely caused by minor injury to the penis. (See penile trauma.) This type of damage is most often caused by vigorous sex (such as bending the penis during penetration or pressure from a partner’s pubic bone), though it can also be caused by sports or other accidents.

Injury to the tunica albuginea may result in scar tissue forming in the cells (fibrosis). This scar tissue then forms the plaque of Peyronie’s disease. Peyronie’s disease is the result of a problem in the way the body heals wounds.

Stages of Peyronie’s

Peyronie’s disease is often split into 2 stages: the acute phase and the chronic phase. During both phases, the bent/curved penis may cause problems with sex. You also may have ED.

Acute Phase: The acute phase usually lasts for 5 to 7 months but can last up to 18 months in rare cases. During this time, the plaques form in the penis, the bending/curving of the penis gets worse and you may feel pain when your penis gets hard.

Chronic Phase: The chronic phase is when the plaque stops growing and the penis doesn’t bend any further. If there was pain with erection during the acute phase, it often will have ended by this time.

Other Factors

Not all men who suffer mild trauma to the penis get Peyronie’s disease. For this reason, most researchers believe there must be genetic or environmental reasons Peyronie’s disease plaques form.

Men with certain connective tissue disorders (such as Dupuytren’s contractures or tympanosclerosis) and men who have a close family member with Peyronie’s disease have a greater risk of getting it.

Certain health issues, such as high blood sugar, tobacco use, or past pelvic trauma, may also lead to wound healing problems and may help cause Peyronie’s disease.

Diagnosis

Your health care provider may be able to tell if you have Peyronie’s disease with only a physical exam. The hard plaques can most often be felt whether the penis is stiff or not. To check how the penis curves, your health care provider may inject a drug into your penis to make it stiff and may take pictures to study.

In some cases, dynamic ultrasound, which uses sound waves to get a picture of what is in your body, is used to see where the plaque is, check for calcium buildup, and show how the blood flows in your penis.

Treatment

In very few cases (about 13 out of 100), Peyronie’s disease goes away without being treated. Most health care experts suggest treating the disease without surgery for the first 12 months after the disease is first noticed.

Men with small plaques, not much curving of the penis, no pain, and no problems with sex may not need to be treated. If you need to be treated, there are many choices.

Oral Drugs

Drug therapy may help men who are badly affected by the disease during the acute phase. Most society guidelines do not recommend oral drugs because long-term studies have not shown convincing benefits.

Oral Vitamin E

Vitamin E is an antioxidant that is popular because of its mild side effects and low cost. Studies as far back as 1948 show that taking vitamin E may make plaques smaller and help straighten the penis.

But most of these studies did not compare a group of people using vitamin E to a group of people who did not (a control group). A few studies of vitamin E that used a control group suggest that vitamin E doesn’t work better than a placebo. (A placebo is a pill with no drugs in it – a “sugar pill.”)

Potassium amino-benzoate

Small studies with placebo controls show that this vitamin B-complex helps reduce plaque size, but not the curve. Unfortunately, it is costly and patients need to take 24 pills per day for 3 to 6 months. It also can upset your stomach, so many men stop taking it.

Tamoxifen

This non-steroidal, anti-estrogen drug has been used to treat desmoid tumors, which are like the plaques in Peyronie’s disease. There are only a few controlled studies of this drug and they haven’t shown that tamoxifen works better than placebo.

Colchicine

Colchicine is an anti-swelling agent that has been shown to be slightly helpful in a few small studies without controls. Many patients taking colchicine to get stomach problems and stop taking the drug. It hasn’t been proven to work better than a placebo.

Carnitine

Carnitine is an antioxidant drug that lowers swelling to help wounds heal. Studies without controls show some benefits. But a recent controlled study didn’t show it to work better than placebo.

Penile Injections

Injecting a drug right into the plaque brings higher doses of the drug to the problem than when a drug is taken by mouth. Plaque injection is often used for men with early Peyronie’s disease or those who aren’t sure they want to have surgery. The skin is often numbed before the shot to reduce pain.

Verapamil injections

Verapamil is mostly used to treat high blood pressure. Some studies suggest that verapamil injection may work for penile pain and curving. Verapamil appears to be a good, low-cost option for the treatment of Peyronie’s disease. More controlled studies are needed to prove how well it works.

Interferon injections

Interferon is a protein made in the body that helps control swelling. It has been shown to help control scarring, perhaps by slowing down the rate that scar tissue builds and by making an enzyme that breaks down the scar tissue. A large-scale test of interferon injection for Peyronie’s disease showed that this treatment might help.

Collagenase injections

Collagenase is made in the body and breaks down certain scar tissues. Studies have shown that injecting collagenase into plaques helped fix Peyronie’s disease. This drug is now approved in the U.S. by the FDA for the treatment of men with penises curving more than 30 degrees.

Stem Cell Therapy for Peyronie’s Disease

Recent advances in stem cell technologies have provided a new possibility of treatment for Peyronie’s disease. Stem cells can be derived from a variety of different sources, but all share the common feature of being able to differentiate into multiple different kinds of cells.

During the process of differentiation, stem cells also produce a variety of chemicals and growth factors that promote the growth and repair of a variety of damaged tissues.

The stem cells also produce chemicals that regulate the body’s immune response, which can reduce inflammation and some of the other negative side effects related to an over-active immune response.

With Peyronie’s disease, in particular, the relevant chemicals secreted by the stem cells during the differentiation process are those that reduce the production of structural proteins that contribute to the formation of the fibrous plaques.

Since the cause of Peyronie’s disease is unknown it is difficult to say for certain exactly what it is about the stem cells that is leading to treatment of the disease, or to what extent the treatment would be successful during the chronic phase of the disease.

In any event, stem cell treatments are known to be safe and relatively non-invasive. Stem cells have been shown to be the best type of stem cell and are widely used for many therapies.

They pose little to no risk of rejection by the body and the entire procedure can be undertaken with only a few injections, which is much less invasive than the kinds of surgeries that would be normally used for treating Peyronie’s disease.

Platelet Rich Plasma for Peyronie’s Disease

Using stem cells is not the only new approach to treating Peyronie’s disease. In recent years, scientists have developed a form of treatment known as platelet-rich plasma therapy that uses key elements from a patient’s own blood to heal damaged tissues.

Platelet-rich plasma therapy extracts blood from a patient and then separates it out into its component pieces by spinning it in a centrifuge. Then the plasma and platelets are taken from the mixture and re-injected into the patient.

The plasma is the part of the blood that consists of liquid and dissolved chemicals, while the platelets are small cell fragments that play a key role in the mechanical and chemical processes involved in clotting and repairing damaged areas in the body.

When re-injected into a patient, these parts of the blood contain key growth factors that help to repair damage in combination with the healing aspects of the platelets.

Platelet-rich plasma therapy uses parts of a patient’s own blood and contains no foreign agents, and therefore does not provoke an immune response. This makes it a very safe form of treatment, while also being minimally invasive.

Surgery

Surgery is reserved for men with more severe, disabling penile deformities that make it hard to have sex. Most health care providers suggest putting off surgery until the plaque and curving have stopped getting worse and the patient has shown no worsening for at least 9 to 12 months.

Before surgery, your health care provider may check the blood flow in the penis by injecting a drug that will make it stiff and may also look at the inside of the penis using ultrasound. These tests help show what is going on inside your penis (such as whether there is also ED) so your health care provider can decide which type of surgery is best for you.

There are 3 basic ways to fix Peyronie’s disease with surgery:

  • making the side of the penis opposite the plaque shorter;
  • making the side of the penis that curves longer;
  • placing a prosthetic device inside the penis if the man has both Peyronie’s disease and erectile dysfunction.

If you need to learn more of the methods of PD treatment, please get in touch with our experts for free.